Investigate into conolidine has triggered discovery of the opioid receptor in the body termed ACKR3/CXCR7. ACKR3 is apparently the most sought after target for conolidine, which also disregards the other 4 classical opioid receptors(three). Conolidine has been present in the tabernaemontana divaricata plant, which is inside the Apocynaceae family. https://bookmarkworm.com/story20787981/considerations-to-know-about-alternative-natural-pain-relief-to-replace-traditional-painkillers