Abstract Metastatic disease is the leading cause of death among cancer patients and involves a complex and inefficient process. Every step of the metastatic process can be rate limiting and is influenced by non-malignant host cells interacting with the tumor cell. Over a century ago. experiments first indicated a link between the immune system and metastasis. https://www.jmannino.com/quick-save-Canon-imageCLASS-MF227dw-Monochrome-Multifunction-Laser-Printer-great-choice/