Pentobarbital will reduce the extent or effect of artemether/lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration with robust CYP3A4 inducers may result in diminished serum concentrations and lack of antimalarial efficacy pentobarbital will raise the level or impact of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 https://georgej396stu4.wikififfi.com/user