Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other indicators through the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interactio... https://robertk925qvy3.salesmanwiki.com/user