This mechanism might be in the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the medical reaction to doxycycline needs to be monitored closely. Phenytoin, sodium valproate, valproic acid: The influence of barbiturates about the metabolism of phenytoin seems to get variable. https://menachemc691bbk5.wikiitemization.com/user