The impairment of HMGB1 function results in amplified mitochondrial DNA harm. While in the SCA1 mouse product, over-expression with the HMGB1 protein through an released virus vector bearing the HMGB1 gene facilitates mend on the mitochondrial DNA destruction, ameliorates the neuropathology and the motor deficits, and extends the lifespan of https://johnz222nyj5.wikinarration.com/user